Table 4.

DAAs used to treat HCV in 2016 and their most common side effects

DAAs and side effects
Sofosbuvir
Fatigue and headaches
Simeprevir
Fatigue,* headaches,* nausea,*† rash (including photosensitivity),† and pruritus†
Daclatasvir*
Fatigue, headaches, anemia, and nausea
Ombitasvir-paritaprevir-ritonavir, and dasabuvir
Fatigue, nausea,‡ pruritus,‡ other skin reactions (eg, rash, erythema, and eczema), insomnia,‡ and asthenia
Ledipasvir-sofosbuvir
Fatigue, headache, and asthenia
Elbasvir-grazoprevir
Fatigue, headache, nausea, and anemia‡
Sofosbuvir-velpatasvir
Headache, fatigue, anemia,‡ nausea,‡ headache, insomnia,‡ and diarrhea‡

^*Most common adverse reactions reported in combination with sofosbuvir and ribavirin.

^†Most common adverse reactions reported with in combination with pegylated IFN-alfa and ribavirin.

^‡Most common adverse reactions reported in combination with ribavirin.