Table 1.

Characterized lncRNAs with potential roles in epigenetic regulation and peptide-mediated regulation

LncRNAs	Target	Functions	References
MEG3	PRC2	Targets the cis or trans of PRC2 to mediate H3K27 methylation and gene silencing for dosage compensation, imprinting, and developmental gene expression	29
LRP1-AS	HMGB2	Modulate the activity of non-histone chromatin modifier HMGB2 to decrease the expression of LRP1	31
H19	DNMT3B	Prevent DNMT3B from DNA methylation through attenuating SAHH hydrolysis to SAH	32
Kcnq1ot1 and Airn	G9a	Targets H3K9 methylase G9a for imprinting	33, 34
Xist	PCR1	Recruit epigenetic complexes to change the status of histones and DNA, and then inactive X chromatin	35, 36
MLN	SERCA	Interact with SERCA and impede Ca2+ uptake into the SR	12
SPAR	mTORC1	Bind to v-ATPase and blunts mTORC1 activation by amino acids	39
HOXB-AS3 peptide	PKM, miR-18	Inhibit tumorigenesis by blocking PKM splicing, PKM2 formation, miR-18a processing, and subsequent metabolic reprogramming in colon cancer (CRC) cells	40