Table S3.
Genotype frequencies of MYCN gene polymorphisms and neuroblastoma susceptibility (divided subjects)
| Genotype | Guangdong province | Henan province | Wenzhou subjects | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| Cases (N=275) | Controls (N=531) | AOR (95% CI)a | P-valuea | Cases (N=118) | Controls (N=281) | AOR (95% CI)a | P-valuea | Cases (N=36) | Controls (N=72) | AOR (95% CI)a | P-valuea | |
| rs57961569 G>A | ||||||||||||
| GG | 124 (45.09) | 230 (43.31) | 1.00 | 64 (54.24) | 113 (40.21) | 1.00 | 14 (38.89) | 29 (40.28) | 1.00 | |||
| GA | 114 (41.45) | 243 (45.76) | 0.87 (0.64–1.19) | 0.371 | 42 (35.59) | 135 (48.04) | 0.54 (0.34–0.86) | 0.009 | 15 (41.67) | 34 (47.22) | 0.93 (0.38–2.28) | 0.877 |
| AA | 37 (13.45) | 58 (10.92) | 1.19 (0.75–1.90) | 0.459 | 12 (10.17) | 33 (11.74) | 0.64 (0.31–1.34) | 0.237 | 7 (19.44) | 9 (12.50) | 1.61 (0.48–5.35) | 0.439 |
| Additive | 1.02 (0.82–1.26) | 0.868 | 0.69 (0.49–0.97) | 0.032 | 1.19 (0.66–2.14) | 0.558 | ||||||
| Dominant | 151 (54.91) | 301 (56.69) | 0.93 (0.69–1.25) | 0.626 | 54 (45.76) | 168 (59.79) | 0.56 (0.36–0.86) | 0.009 | 22 (61.11) | 43 (59.72) | 1.07 (0.46–2.47) | 0.876 |
| Recessive | 238 (86.55) | 473 (89.06) | 1.28 (0.82–1.99) | 0.272 | 106 (89.83) | 248 (88.26) | 0.86 (0.43–1.74) | 0.677 | 29 (80.56) | 63 (87.50) | 1.67 (0.56–5.01) | 0.359 |
| rs9653226 T>C | ||||||||||||
| TT | 93 (33.82) | 181 (34.09) | 1.00 | 30 (25.42) | 92 (32.74) | 1.00 | 15 (41.67) | 20 (27.78) | 1.00 | |||
| TC | 124 (45.09) | 262 (49.34) | 0.91 (0.66–1.27) | 0.584 | 62 (52.54) | 141 (50.18) | 1.34 (0.81–2.23) | 0.261 | 16 (44.44) | 36 (50.00) | 0.57 (0.23–1.41) | 0.225 |
| CC | 58 (21.09) | 88 (16.57) | 1.29 (0.85–1.96) | 0.228 | 26 (22.03) | 48 (17.08) | 1.61 (0.86–3.04) | 0.140 | 5 (13.89) | 16 (22.22) | 0.40 (0.12–1.36) | 0.142 |
| Additive | 1.10 (0.90–1.36) | 0.354 | 1.28 (0.93–1.74) | 0.129 | 0.62 (0.34–1.12) | 0.115 | ||||||
| Dominant | 182 (66.18) | 350 (65.91) | 1.01 (0.74–1.37) | 0.964 | 88 (74.58) | 189 (67.26) | 1.41 (0.87–2.29) | 0.166 | 21 (58.33) | 52 (72.22) | 0.52 (0.22–1.22) | 0.132 |
| Recessive | 217 (78.91) | 443 (83.43) | 1.36 (0.94–1.97) | 0.101 | 92 (77.97) | 233 (82.92) | 1.34 (0.78–2.29) | 0.293 | 31 (86.11) | 56 (77.78) | 0.56 (0.19–1.68) | 0.299 |
| rs13034994 A>G | ||||||||||||
| AA | 166 (60.36) | 300 (56.50) | 1.00 | 77 (65.25) | 176 (62.63) | 1.00 | 22 (61.11) | 50 (69.44) | 1.00 | |||
| AG | 90 (32.73) | 202 (38.04) | 0.80 (0.59–1.10) | 0.171 | 32 (27.12) | 89 (31.67) | 0.84 (0.51–1.36) | 0.472 | 12 (33.33) | 20 (27.78) | 1.41 (0.58–3.42) | 0.444 |
| GG | 19 (6.91) | 29 (5.46) | 1.18 (0.64–2.17) | 0.602 | 9 (7.63) | 16 (5.69) | 1.37 (0.58–3.26) | 0.476 | 2 (5.56) | 2 (2.78) | 2.39 (0.31–18.51) | 0.404 |
| Additive | 0.93 (0.73–1.19) | 0.577 | 1.01 (0.70–1.44) | 0.974 | 1.47 (0.72–3.00) | 0.294 | ||||||
| Dominant | 109 (39.64) | 231 (43.50) | 0.85 (0.63–1.14) | 0.284 | 41 (34.75) | 105 (37.37) | 0.91 (0.58–1.44) | 0.698 | 14 (38.89) | 22 (30.56) | 1.50 (0.64–3.50) | 0.348 |
| Recessive | 256 (93.09) | 502 (94.54) | 1.28 (0.70–2.33) | 0.422 | 109 (92.37) | 265 (94.31) | 1.45 (0.6–3.41) | 0.391 | 34 (94.44) | 70 (97.22) | 2.14 (0.28–16.16) | 0.463 |
| rs60226897 G>A | ||||||||||||
| GG | 130 (47.27) | 262 (49.34) | 1.00 | 64 (54.24) | 117 (41.64) | 1.00 | 14 (38.89) | 31 (43.06) | 1.00 | |||
| GA | 116 (42.18) | 215 (40.49) | 1.09 (0.80–1.48) | 0.600 | 43 (36.44) | 130 (46.26) | 0.59 (0.37–0.94) | 0.028 | 15 (41.67) | 33 (45.83) | 1.05 (0.43–2.57) | 0.919 |
| AA | 29 (10.55) | 54 (10.17) | 1.09 (0.66–1.80) | 0.727 | 11 (9.32) | 34 (12.10) | 0.60 (0.28–1.26) | 0.176 | 7 (19.44) | 8 (11.11) | 1.98 (0.59–6.63) | 0.270 |
| Additive | 1.06 (0.85–1.32) | 0.604 | 0.70 (0.50–0.98) | 0.037 | 1.32 (0.74–2.38) | 0.350 | ||||||
| Dominant | 145 (52.73) | 269 (50.66) | 1.09 (0.81–1.46) | 0.574 | 54 (45.76) | 164 (58.36) | 0.60 (0.39–0.92) | 0.019 | 22 (61.11) | 41 (56.94) | 1.23 (0.53–2.85) | 0.624 |
| Recessive | 246 (89.45) | 477 (89.83) | 1.05 (0.65–1.70) | 0.835 | 107 (90.68) | 247 (87.90) | 0.76 (0.37–1.56) | 0.453 | 29 (80.56) | 64 (88.89) | 1.93 (0.63–5.87) | 0.248 |
| Combined effect of risk genotypesb | ||||||||||||
| 0 | 131 (47.64) | 239 (45.01) | 1.00 | 47 (39.83) | 152 (54.09) | 1.00 | 21 (58.33) | 37 (51.39) | 1.00 | |||
| 1 | 24 (8.73) | 78 (14.69) | 0.56 (0.34–0.93) | 0.025 | 12 (10.17) | 22 (7.83) | 1.83 (0.84–3.99) | 0.130 | 1 (2.78) | 7 (9.72) | 0.23 (0.03–2.07) | 0.191 |
| 2 | 53 (19.27) | 111 (20.90) | 0.86 (0.58–1.28) | 0.458 | 26 (22.03) | 49 (17.44) | 1.79 (1.00–3.21) | 0.049 | 8 (22.22) | 13 (18.06) | 1.10 (0.39–3.15) | 0.859 |
| 3 | 67 (24.36) | 103 (19.40) | 1.20 (0.82–1.74) | 0.349 | 33 (27.97) | 58 (20.64) | 1.84 (1.07–3.16) | 0.027 | 6 (16.67) | 15 (20.83) | 0.66 (0.22–2.02) | 0.469 |
| Trend | 1.04 (0.92–1.17) | 0.520 | 1.24 (1.04–1.47) | 0.014 | 0.92 (0.66–1.29) | 0.629 | ||||||
| 0–1 | 155 (56.36) | 317 (59.70) | 1.00 | 59 (50.00) | 174 (61.92) | 1.00 | 22 (61.11) | 44 (61.11) | 1.00 | |||
| 2–3 | 120 (43.64) | 214 (40.30) | 1.15 (0.85–1.54) | 0.362 | 59 (50.00) | 107 (38.08) | 1.65 (1.07–2.55) | 0.024 | 14 (38.89) | 28 (38.89) | 1.00 (0.43–2.31) | 0.999 |
Notes:
a
Adjusted for age and gender.
b
Risk genotypes were rs57961569 GG, rs9653226 CC, rs13034994 GG, and rs60226897 GG.
Abbreviations: AOR, adjusted odds ratio; CI, confidence interval.