Table 2.
Characteristics of the study population according to the severity grade of the DBPCFC reaction
| Grade 0 (n = 78) | Grade 1 (n = 160) | Grade 2 (n = 55) | Grade 3 (n = 171) | Grade 4 (n = 270) | |
|---|---|---|---|---|---|
| Age (y), median (IQR) | (5.78) 2.32‐11.44 | 4.76 (2.00‐7.63) | 6.24 (4.34‐9.52) | 5.39 (3.16‐8.33) | 7.99 (5.29‐12.12) |
| Gender, n (%) | |||||
| Female | 32 (41.0) | 69 (43.1) | 22 (40.0) | 65 (38.0) | 110 (40.7) |
| Male | 46 (59.0) | 91 (56.9) | 33 (60.0) | 106 (62.0) | 160 (59.3) |
| Food, n (%) | |||||
| Cashew nut | 7 (9.0) | 19 (11.9) | 15 (27.3) | 31 (18.1) | 55 (20.4) |
| Cow's milk | 35 (44.9) | 45 (28.1) | 7 (12.7) | 31 (18.1) | 32 (11.9) |
| Hazelnut | 11 (14.1) | 17 (10.6) | 3 (5.5) | 10 (5.8) | 42 (15.6) |
| Hen's egg | 3 (3.8) | 26 (16.3) | 8 (14.5) | 36 (21.1) | 17 (6.3) |
| Peanut | 22 (28.2) | 53 (33.1) | 22 (40.0) | 63 (36.8) | 124 (45.9) |
| sIgE (kU/L), median (IQR) | 2.71 (0.30‐23.20) | 2.99 (0.96‐14.08) | 8.40 (2.11‐40.20) | 11.75 (2.48‐41.80) | 12.10 (2.83‐51.10) |
| SPT wheal ratio, median (IQR) | 1.00 (0.00‐1.55) | 1.30 (0.90‐1.88) | 1.30 (0.90‐2.00) | 1.50 (1.10‐2.00) | 1.70 (1.30‐2.20) |
| Estimation of SPT wheal size (mm), median (IQR)a | 10.0 (0‐15.5) | 13.0 (9.0‐18.8) | 13.0 (9.0‐20.0) | 15.0 (11.0‐20.0) | 17 (13.0‐22.0) |
| ED (mg protein), median (IQR) | 1750.00 (350.00‐1750.00) | 98.00 (3.50‐350.00) | 139.20 (21.00‐580.00) | 70.00 (14.00‐350‐00) | 58.00 (1.75‐307.93) |
| CD (mg protein), median (IQR) | 2189.25 (577.97‐2189.25) | 141.12 (5.25‐577.97) | 226.49 (30.80‐837.52) | 89.25 (19.18‐559.58) | 83.52 (1.75‐433.68) |
| Reaction time during the DBPCFC (minutes), median (IQR) | 55.00 (15.00‐60.00) | 25.00 (5.50‐60.00) | 12.50 (5.00‐32.50) | 20.0 (5.00‐45.00) | 15.0 (5.0‐37.0) |
| History of asthma, n (%) | |||||
| Yes | 34 (43.6) | 70 (43.8) | 28 (50.9) | 78 (45.6) | 155 (57.4) |
| No | 41 (52.6) | 89 (55.6) | 24 (43.6) | 91 (53.2) | 110 (40.7) |
| History of atopic dermatitis, n (%) | |||||
| Yes | 60 (76.9) | 150 (93.8) | 42 (76.4) | 157 (91.8) | 232 (85.9) |
| No | 17 (21.8) | 9 (5.6) | 11 (20.0) | 13 (7.6) | 36 (13.3) |
| History of rhinoconjunctivitis, n (%) | |||||
| Yes | 26 (33.3) | 45 (28.1) | 14 (25.5) | 59 (34.5) | 125 (46.3) |
| No | 49 (62.8) | 110 (68.8) | 38 (69.1) | 107 (62.6) | 138 (51.1) |
| Severity of most severe accidental reaction, n (%) | |||||
| Grade 0 | 10 (12.8) | 34 (21.3) | 11 (20.0) | 39 (22.8) | 48 (17.8) |
| Grade 1 | 11 (14.1) | 33 (20.6) | 6 (10.9) | 13 (7.6) | 23 (8.50 |
| Grade 2 | 18 (23.1) | 30 (18.8) | 10 (18.2) | 22 (12.9) | 40 (14.8) |
| Grade 3 | 13 (16.7) | 32 (20.0) | 12 (21.8) | 40 (23.4) | 58 (21.5) |
| Grade 4 | 26 (33.3) | 31 (19.4) | 16 (29.1) | 57 (33.3) | 101 (37.4) |
CD, cumulative dose; DBPCFC, double‐blind, placebo‐controlled food challenge; ED, eliciting dose; IQR, interquartile range; sIgE, specific immunoglobulin E; SPT, skin prick test.
a
The estimations of the SPT wheal size were calculated with a histamine wheal size of 10 mm.