Table 2.

Predictors of liver‐related clinical outcomes; elastin content and serum alkaline phosphatase (ALP) are the only significant predictors of a liver‐related clinical event, as determined by univariate Cox regression analysis

Variable	Exp(B)	95% CI	P‐value
Age (years)	1.059	0.989–1.134	0.100
Male gender	0.405	0.137–1.198	0.103
BMI (kg/m2)	1.093	0.961–1.245	0.177
Estimated duration from infection to biopsy (years)	1.011	0.955–1.071	0.704
Past heavy alcohol use	1.371	0.464–4.049	0.568
Heavy alcohol use (>50 units/week)	1.980	0.707–5.544	0.194
Genotypea	1.889	0.588–6.070	0.286
Albumin (g/l)	0.947	0.868–1.034	0.947
Bilirubin (μmol/ml)	1.031	0.960–1.107	0.404
ALP (u/l)	1.010	1.004–1.015	0.001
GGT (u/l)	1.001	0.999–1.003	0.279
ALT (u/l)	0.994	0.987–1.001	0.088
Ishak stageb	1.307	0.500–3.415	0.584
Laennec stage 3 (reference)
4A	0.490	0.030–7.961	0.616
4B	0.661	0.068–6.399	0.721
4C	2.058	0.265–16.005	0.490
Ishak grade, 0–6 versus 7–18	0.890	0.334–2.372	0.816
PSR (collagen) (%)	1.010	0.947–1.078	0.758
Elastin (%)	1.226	1.007–1.493	0.042
ALBI score	1.836	0.759–4.439	0.178

ALBI, albumin–bilirubin; ALT, alanine transaminase; BMI, body mass index; CI, confidence interval; GGT, γ‐glutamyl transferase; PSR, picrosirius red.

^aGenotype 1 used as reference; analysis performed with comparison of only genotypes 1 and 3.

^bIshak stage 5 used as reference standard.