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High concentrations of IgG (ie, greater than 20 g/l) lead to rapid catabolism and shorter survival in the circulation (half‐life). At an IgG concentration of 30 g/l (30 mg/ml as shown here) for example, shortly after an IVIG infusion the half‐life would be 11 days (red dashed line). In contrast, at a normal serum IgG concentration (8 g/l) the half‐life is 28 days (Waldmann and Strober, 1969 ). Copyright 2016 Karger Publishers, Basel, Switzerland. Reprinted with permission.
