Age‐standardized, delay‐adjusted incidence rates and recent trends (2010‐2014) are illustrated for the 17 most common cancers in men and the 18 most common cancers in women for all races/ethnicities combined and by sex. The 5‐year average annual percent change (AAPC) is based on the joinpoint trend from 1999 to 2014. An asterisk indicates that the AAPC is statistically significantly different from zero (2‐sided t test or Z test; P < .05). Rates were age‐standardized to the 2000 US standard population (19 age groups; Census P25‐1130), were delay‐adjusted, and covered 89% of the US population. The following registries were included in the analyses: Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Missouri, Montana, Nebraska, New Hampshire, New Jersey, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, Texas, Utah, Vermont, Washington, West Virginia, Wisconsin, and Wyoming. The AAPC is a weighted average of the annual percent changes (APCs) over the fixed interval (2010‐2014) using the underlying joinpoint model for the period from 1999 to 2014. Joinpoint models with up to 2 joinpoints are based on rates per 100,000 persons age standardized to the 2000 US standard population (19 age groups; Census P25‐1130). For joinpoint analysis, the Joinpoint Regression Program was used (version 4.5.0.1; Bethesda, MD: Statistical Research and Applications Branch, National Cancer Institute; June 2017).