Table 4.
Clinical characteristics of patients with clinical worsening, poor functional outcomes, and severe disability.
| Clinical worsening | Poor function outcomes, mRS ≥ 4 | Severe disability, BI ≤ 30 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Yes | No | p | Yes | No | p | Yes | No | p | |
| N | 13 | 25 | 30 | 8 | 21 | 17 | |||
| Female (%) | 8 (61.5) | 11 (44.0) | 0.30 | 16 (53.3) | 3 (37.5) | 0.69 | 13 (61.9) | 6 (35.3) | 0.10 |
| Age (years) | 71.6 (17.7) | 68.4 (13.4) | 0.53 | 71.1 (14.5) | 63.2 (15.8) | 0.90 | 70.8 (16.1) | 67.8 (13.5) | 0.54 |
| NIHSS | 16.9 (8.7) | 16.6 (7.4) | 0.91 | 17.7 (7.9) | 12.8 (7.3) | 0.11 | 19.0 (7.2) | 13.9 (8.0) | 0.04 |
| HTN (%) | 12 (92.3) | 15 (60.0) | 0.03 | 23 (76.7) | 4 (50.0) | 0.19 | 17 (80.9) | 10 (58.8) | 0.13 |
| DM (%) | 7 (53.8) | 5 (20.0) | 0.03 | 12 (40.0) | 0 (0.0) | 0.03 | 9 (42.8) | 3 (17.6) | 0.09 |
| CAD (%) | 4 (30.7) | 5 (32.0) | 0.69 | 7 (23.3) | 2 (25.0) | 1.0 | 5 (23.8) | 4 (23.5) | 0.98 |
| CKD (%) | 5 (38.4) | 2 (8.0) | 0.20 | 6 (20.0) | 1 (12.5) | 1.0 | 5 (23.8) | 2 (11.7) | 0.33 |
| Smoker (%) | 1 (7.69) | 8 (32.0) | 0.12 | 7 (23.3) | 2 (25.0) | 1.0 | 5 (23.8) | 4 (23.5) | 0.98 |
| Hemoglobin (g/dl) | 12.7 (3.17) | 14.5 (2.3) | 0.05 | 13.7 (3.0) | 14.2 (1.3) | 0.66 | 13.0 (3.2) | 14.9 (1.5) | 0.02 |
| Platelets (103/μl) | 212 (108) | 215 (45) | 0.98 | 219 (77) | 197 (31) | 0.45 | 218 (92) | 209 (30) | 0.69 |
| WBC (103/mm3) | 12.0 (6.6) | 10.5 (3.7) | 0.37 | 10.2 (3.2) | 11.3 (5.3) | 0.60 | 11.6 (5.6) | 10.0 (2.9) | 0.37 |
| BUN (mg/dl) | 23.2 (14.7) | 21.1 (11.2) | 0.68 | 27.0 (19.0) | 19.5 (7.2) | 0.15 | 26.2 (3.4) | 18.0 (3.4) | 0.09 |
| Creatinine (mg/dl) | 2.41 (2.85) | 1.05 (0.41) | 0.02 | 1.66 (1.96) | 0.94 (0.17) | 0.31 | 1.92 (2.3) | 1.03 (0.36) | 0.12 |
| CRP (mg/dl) | 10.9 (10.1) | 2.8 (4.3) | 0.02 | 6.0 (7.9) | 1.7 (1.1) | 0.30 | 8.48 (9.0) | 1.66 (1.0) | 0.03 |
| IV-t-PA (%) | 1 (7.69) | 12 (48.0) | 0.01 | 8 (26.7) | 5 (62.5) | 0.09 | 1 (4.7) | 12 (70.6) | 0.001 |
| TSPO | 0.58 (0.53) | 0.30 (0.57) | 0.02 | 0.53 (0.61) | 0.08 (0.33) | 0.003 | 0.58 (0.47) | 0.19 (0.61) | 0.03 |
Values are mean (standard deviation) or n (%), as appropriate. TSPO values (ng/ml) are median (interquartile range). NIHSS, National Institutes of Health Stroke Scale; HTN, hypertension; DM, diabetes mellitus; CAD, coronary artery disease; CKD, chronic kidney disease; WBC, white blood count; CRP, highly sensitive C-reactive protein; IV-t-PA, intravenous tissue plasminogen activator; TSPO, translocator protein.