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. 2018 Jul 4;20:64. doi: 10.1186/s13058-018-0978-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Performance of the radiosensitivity signature (RSS) (a) and the 10-gene score (10-GS) (b) in the Nanostring data generated with the targeted radiosensitivity gene expression assay. Tumors classified as a case by RSS, or above the median 10-GS score, were regarded high risk. The prognostic performance was evaluated with the Kaplan-Meier method and log-rank test for endpoint ipsilateral breast tumor recurrence, stratified for estrogen receptor (ER) status and radiotherapy (RT). The treatment predictive effect was evaluated by analyzing the effect of RT in samples classified as radioresistant or radiosensitive by the respective classifiers (c)