Table 2.
Intensity of HIF-1alpha and CAIX compared to clinicopathological variables in pancreatic ductal adenocarcinoma. Statistically significant p values are italicized
| Variable | n/N | Nuclear HIF-1alpha intensity, n | n/N | Membranous CAIX intensity, n | ||||
|---|---|---|---|---|---|---|---|---|
| Weak | Strong | p | Weak | Strong | p | |||
| pT | ||||||||
| T1 | 4/64 | 1 | 3 | 0.439 | 4/65 | 4 | 0 | 0.533 |
| T2 | 22/64 | 11 | 11 | 22/65 | 15 | 7 | ||
| T3 | 32/64 | 20 | 12 | 33/65 | 23 | 10 | ||
| T4 | 6/64 | 4 | 2 | 6/65 | 5 | 1 | ||
| Lymph nodes | ||||||||
| Positive | 31/64 | 16 | 15 | 0.556 | 32/65 | 23 | 9 | 0.823 |
| Negative | 32/64 | 19 | 13 | * | 32/65 | 23 | 9 | * |
| Stage | ||||||||
| I | 18/63 | 7 | 11 | 0.236 | 18/64 | 13 | 5 | 0.794 |
| II | 39/63 | 24 | 15 | * | 40/64 | 28 | 12 | * |
| III–IV | 6/63 | 4 | 2 | 6/64 | 5 | 1 | ||
| Tumor grade | ||||||||
| 1 | 9/63 | 4 | 5 | 0.351 | 9/64 | 6 | 3 | 0.344 |
| 2 | 28/63 | 17 | 11 | ** | 28/64 | 22 | 6 | ** |
| 3 | 13/63 | 9 | 4 | 13/64 | 11 | 2 | ||
| Tumor size | ||||||||
| > 30 mm | 42/64 | 23 | 19 | 0.475 | 43/65 | 30 | 13 | 0.370 |
| < 30 mm | 22/64 | 13 | 9 | 22/65 | 17 | 5 | ||
| BMI | ||||||||
| > 25 | 25/43 | 15 | 10 | 0.366 | 26/44 | 19 | 7 | 0.186 |
| < 25 | 18/43 | 9 | 9 | *** | 18/44 | 16 | 2 | *** |
| Sex | ||||||||
| Male | 35/64 | 19 | 16 | 0.463 | 35/65 | 29 | 6 | 0.038 |
| Female | 29/64 | 17 | 12 | 30/65 | 18 | 12 | ||
*Lymph node status was unavailable for one patient
**Tumor grade was missing from 16 patients
***BMI was available only for 47 patients