Table 4.
Pharmacokinetic parameters for six compounds in rat plasma after oral administration of raw/honey-roasting licorice (n = 5).
| Analytes | Group | Cmax (ng/mL) | Tmax (h) | AUC0-24h (h·ng /mL) |
|---|---|---|---|---|
| LA | 25% honey-roasting | 38.49 ± 13.09 | 0.8 | 64.77 ± 17.97∗ |
| 50% honey-roasting | 31.21 ± 8.09∗ | 0.9 | 56.30 ± 14.34 | |
| Raw | 55.46 ± 13.51 | 0.7 | 82.31 ± 19.00 | |
| LQ | 25% honey-roasting | 202.93 ± 54.12 | 0.6 | 478.69 ± 65.22 |
| 50% honey-roasting | 87.93 ± 8.08∗Δ | 0.5 | 318.94 ± 49.99∗Δ | |
| Raw | 191.00 ± 80.23 | 0.6 | 520.48 ± 94.53 | |
| ILQ | 25% honey-roasting | 24.80 ± 3.63∗ | 0.7 | 260.44 ± 8.53 |
| 50% honey-roasting | 20.59 ± 5.82∗ | 0.4 | 246.22 ± 7.67Δ | |
| Raw | 47.76 ± 2.62 | 0.4 | 257.39 ± 19.28 | |
| LG | 25% honey-roasting | 12.02 ± 3.67 | 2.3 | 85.36 ± 14.70 |
| 50% honey-roasting | 5.46 ± 1.61∗Δ | 2.5 | 47.74 ± 8.03∗Δ | |
| Raw | 12.11 ± 5.07 | 2.4 | 84.29 ± 33.71 | |
| ILG | 25% honey-roasting | 1.12 ± 0.25 | 1.5 | 9.32 ± 0.68∗ |
| 50% honey-roasting | 0.56 ± 0.12Δ | 1.8 | 6.13 ± 0.80Δ | |
| Raw | 0.75 ± 0.28 | 1.5 | 6.53 ± 2.34 | |
| GA | 25% honey-roasting | 650.93 ± 199.95 | 6.8 | 6995.30 ± 1293.79 |
| 50% honey-roasting | 607.78 ± 277.70 | 6.8 | 5177.10 ± 2540.93 | |
| Raw | 571.98 ± 311.21 | 8.0 | 6979.29 ± 4803.95 |
∗P<0.05, compared with the raw group. ΔP<0.05, compared with the 25% honey-roasting group. n: the number of rats.