FIG. 11.
Terminal, ipsilateral hemidiaphragm electromyography (EMG) activity post-injury and treatment. (A) Bar graphs represent the average burst amplitudes during baseline activity (± standard deviation) for each group: vehicle (HBSS) treated with or without immunosuppression (+CSA), Sprague-Dawley–derived fetal spinal cord tissue (SD-FSC) transplantation, and GFP-expressing Fisher–derived tissue (GFP-FSC) transplantation with immunosuppression (+CSA). Averages were calculated from 40-sec samples of integrated activity during eupneic (20% O2) breathing. (B) The average percent changes (± standard deviation) in burst amplitude in response to a respiratory challenge (hypoxia, 10% O2) for each group. Individual data points have been overlaid to show the extent of variability in each group. CSA, cyclosporine A; FSC, fetal spinal cord; GFP, green fluorescent protein; HBSS, Hank's balanced salt solution. Color image is available online at www.liebertpub.com/neu