Table 3. Multivariable analysis for cause-specific survival.
| Endometrial cancer with synchronous ovarian cancer | Epithelial ovarian cancer with synchronous endometrial cancer | |||
|---|---|---|---|---|
| HR (95%CI) | P-value | HR (95%CI) | P-value | |
| Age (y) | ||||
| < 40 | 1 | 1 | ||
| 40-49 | 1.26 (1.14-1.39) | <0.001 | 1.51 (1.43-1.59) | <0.001 |
| 50-59 | 1.61 (1.47-1.76) | <0.001 | 1.82 (1.73-1.91) | <0.001 |
| ≥60 | 3.39 (3.10-3.71) | <0.001 | 2.77 (2.65-2.91) | <0.001 |
| Ethnicity | ||||
| White | 1 | 1 | ||
| Black | 1.75 (1.69-1.80) | <0.001 | 1.21 (1.17-1.25) | <0.001 |
| Hispanic | 1.13 (1.09-1.18) | <0.001 | 0.97 (0.94-1.01) | 0.11 |
| Asian | 0.97 (0.92-1.02) | 0.26 | 0.91 (0.87-0.95) | <0.001 |
| Others | 1.06 (0.97-1.15) | 0.20 | 0.96 (0.90-1.04) | 0.34 |
| Marital status | ||||
| Single | 1 | 1 | ||
| Married | 0.82 (0.80-0.85) | <0.001 | 0.86 (0.83-0.88) | <0.001 |
| Others | 1.16 (1.13-1.20) | <0.001 | 1.08 (1.05-1.11) | <0.001 |
| Registry Area | ||||
| West | 1 | 1 | ||
| Central | 1.05 (1.03-1.08) | 0.011 | 1.06 (1.04-1.08) | <0.001 |
| East | 1.03 (1.01-1.06) | 0.009 | 0.94 (0.92-0.96) | <0.001 |
| Year at diagnosis | ||||
| 1973-1979 | 1 | 1 | ||
| 1980-1989 | 1.28 (1.23-1.34) | <0.001 | 1.00 (0.96-1.03) | 0.89 |
| 1990-1999 | 1.56 (1.49-1.63) | <0.001 | 1.05 (1.01-1.08) | 0.005 |
| 2000-2009 | 1.58 (1.51-1.64) | <0.001 | 1.01 (0.98-1.04) | 0.48 |
| 2010-2013 | 1.53 (1.45-1.61) | <0.001 | 0.84 (0.81-0.88) | <0.001 |
| Stage | ||||
| I | 1 | 1 | ||
| II | 3.04 (2.90-3.19) | <0.001 | 2.57 (2.44-2.70) | <0.001 |
| III | 6.19 (5.99-6.39) | <0.001 | 5.73 (5.52-5.94) | <0.001 |
| IV | 19.4 (18.9-20.0) | <0.001 | 9.21 (8.88-9.54) | <0.001 |
| Unknown | 4.07 (3.95-4.21) | <0.001 | 6.23 (5.95-6.53) | <0.001 |
| Tumor size (cm) | ||||
| < 2.0 (or 10*) | 1 | 1 | ||
| ≥ 2.0 (or 10*) | 1.78 (1.68-1.89) | <0.001 | 0.94 (0.92-0.97) | <0.001 |
| Unknown | 1.86 (1.76-1.97) | <0.001 | 1.29 (1.26-1.31) | <0.001 |
| Histology patterns† | ||||
| Non-synchronous | 1 | 1 | ||
| Group 1 (E/E) | 0.79 (0.68-0.93) | 0.005 | 0.44 (0.39-0.50) | <0.001 |
| Group 2 (E/NE) | 1.58 (1.39-1.79) | <0.001 | 0.54 (0.39-0.73) | <0.001 |
| Group 3 (NE/E) | 0.94 (0.66-1.34) | 0.73 | 0.78 (0.70-0.86) | <0.001 |
| Group 4 (NE/NE) | 1.57 (1.34-1.83) | <0.001 | 0.96 (0.85-1.10) | 0.57 |
Cox proportional hazard regression models for cause-specific survival. All the listed covariates were entered in the final models. Significant P-values are emboldened. Unadjusted-HR is listed in Supplementary Table 6. *cutoff for ovarian cancer. †histology types for the primary tumor followed by the synchronous tumor are shown inside the brackets. Abbreviations: HR, hazard ratio; CI, confidence interval; E, endometrioid; and NE, non-endometrioid.