Table 3. Summary of cases with discordant data between immunohistochemistry and molecular MSI analysis.
Sample ID | IHC status | MLH1 | MSH2 | MSH6 | PMS2 | Molecular MSI status | HSP110 (T17) status |
---|---|---|---|---|---|---|---|
11.0011 | negative | + | + | + | - | MSS | altereda |
12.0767 | negative | - | + | + | - | MSS | altereda |
11.0226 | negative | + | + | - | + | MSI-L | altereda |
13.0395 | negative | + | + | + | - | MSI-L | altereda |
11.0404 | positive | + | + | + | + | MSI-H | altered |
11.0827 | positive | + | + | + | + | MSI-H | altered |
13.0578 | positive | + | + | + | + | MSI-H | altered |
13.1023 | positive | + | + | + | + | MSI-H | altered |
HSP110 (T17) status obtained by comparison between normal and tumor tissue DNA from the samples and also by R method.
+: positive protein expression; -: negative protein expression; MSS: microsatellite stability; MSI-L: low-microsatellite instability; MSI-H: high-microsatellite instability; a: analyzed by R method.