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. 2018 Jun 19;9(47):28702–28716. doi: 10.18632/oncotarget.25614

Figure 1. Lytic and immunogenic effects of NDV in human bladder cancer cells.

Figure 1

Human bladder cancer cell lines were co-cultured with NDV or media for 24 h at a multiplicity of infection (MOI) of 2. (A) Viability measured by MTT proliferation assay at 24 hours. (B) Percent cell viability calculated from (A). (C–D) Surface upregulation of calreticulin, MHCI and MHCII at 24 hours quantified by flow cytometry: left: representative histograms using NDV-infected T24 bladder cancer cell line; right: summary bar graphs. (E) Correlation of upregulation of calreticulin, MHC I, and MHC II with % viability in NDV-treated human bladder cancer cell lines. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns: non-significant. MFI: median fluorescence intensity. Data represent one of 2 independent experiments with 3 replicates per group.