Figure 6. PD-1 blockade potentiates the regression of NDV-treated and distant tumors.

Animals bearing bilateral flank MB49 bladder tumors were treated with 4 injections of NDV administered every other day into right tumor combined with concomitant intraperitoneal injection of aPD-1 antibodies or PBS. (A) Treatment schema. (B) Overall Survival. (C) Growth of individual treated and distant tumors. (D) Mean tumor volumes. Tumor growth curves stop at the time of first animal death in each group. Statistical comparisons were performed at the time of first animal death. (B–C) data pooled from two independent experiments with 5–10 mice per group. (D) Representative experiment with 5–10 mice per group. ^*p < 0.05, ^**p < 0.01. Mean ± SEM are shown.