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. 2018 Jun 19;9(47):28731–28744. doi: 10.18632/oncotarget.25618

Figure 2. Synergistic effect of RO3280 and rhTRAIL combined treatment in NSCLC cells.

Figure 2

Cells were cultured simultaneously with 50 nM RO3280 and 20 ng/ml rhTRAIL (A, B) and an increased concentration of RO3280 (nM) and rhTRAIL (ng/ml): 1) 0:0; 2) 0.05:0.02; 3) 0.5:0.2; 4) 5:2; 5) 50:20; 6) 500:200; 7) 5000:2000 (C). Cell viability was analyzed by MTS assays after 72 hrs incubation (A) or at indicated time points (n = 4, mean ± SD) (B). The combination index/fraction affected curve was calculated with the Compusyn program (C).