Figure 1. LipA cured tumor-bearing rats.

(A) The lifespan of tumor-bearing rats was improved by LipA treatment. Fourteen days after i.p. injection of PROb cells, rats were treated i.v. with LipA (grey) or physiological solution (control, black) 3 times per week for 5 weeks. Results are representative of at least 3 independent experiments with 10 animals per group. (B) Hematoxylin-eosin staining of tumors from LipA treated or control rats (scale bars = 200 µm). (C) Enlargement of regions outlined in figure B (scale bars = 50 µm). The tumor core and surrounding ring of cells can be distinguished. (D) Tumor regression was analyzed by immunostaining of tumor cells (anti-cytokeratin Ab, red), one day after the first (day 15) and the fourth injection (day 22) of LipA or physiological solution (scale bars = 50 µm). Micrographs are representative of at least 3 independent experiments, 4 animals per group.