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. 2018 Jun 19;9(47):28445–28455. doi: 10.18632/oncotarget.25442

Figure 2. Activation of the non-canonical pathway induces angiogenesis in the 3D tumor-stroma model.

Figure 2

(A) Confocal microscopic images of spheroids containing ECs (HUVEC), fibroblasts (NHDF) and colorectal cancer cells (Colo320) stimulated with activators of the non-canonical pathway lymphotoxin (LT) or LIGHT as compared to controls unstimulated and growth factors VEGF/bFGF (GF). (B) Quantification of cumulative sprout length in spheroids unstimulated or stimulated with LT, LIGHT or GF. (n = 19–38 spheroids per condition). (**represents p < 0.01; ***represents p < 0.001, ****represents p < 0.0001).