Table 1. NHERF1 IHC patterns in meningioma and other chordoid/myxoid tumors.
| Diagnosis | WHO | Patients | Tumor location | NHERF1 IHC | |||||
|---|---|---|---|---|---|---|---|---|---|
| grade | No. cases Gender |
Median age (range, yrs) |
NSB | SB | SC | V | Focal1 | Diffuse1 | |
| (% + cases) | |||||||||
| Grade I2 Mng | I | 13 (11F; 2M) | 49 (33–85) | 8 | 2 | 3 | 0 | 0 | 0 |
| Secretory3 Mng | I | 12 (9F; 3M) | 55.5 (39–69) | 5 | 7 | 0 | 0 | 8 | 92 |
| Part chordoid Mng4 | I II |
3 (3F; 0M) 4 (0F; 4M) |
60 (51–68) 58.5 (35–78) |
0 1 |
3 2 |
0 0 |
0 1 |
33 25 |
67 75 |
| Chordoid Mng | II | 25 (17F; 8M) | 45 (29–87) | 12 | 13 | 0 | 0 | 12 | 72 |
| Atypical Mng | II | 20 (12F; 8M) | 59.5 (31–84) | 13 | 7 | 0 | 0 | 10 | 10 |
| Anaplastic Mng | III | 3 (2F; 1M) | 44 (30–58) | 2 | 1 | 0 | 0 | 0 | 67 |
| Clear Cell Mng | II | 3 (2F; 1M) | 44 (14, 67) | 1 | 1 | 0 | 1 | 33 | 67 |
| Chordoma | 8 (6F; 2M) | 50.5 (15–65) | 0 | 6 | 2 | 0 | Membrane 62% | ||
| Chordoid glioma | II | 2 (2M) | 43 (40, 46) | 0 | 0 | 0 | 2 | Membrane 50% | |
| Chondrosarcoma | I-II | 2 (1F; 1M) | 47 (32, 62) | 0 | 2 | 0 | 0 | Negative | |
Abbreviations: NSB, non-skull base (hemisphere convexity/falx); SB, skull base; SC, spinal cord; V, ventricular; M, male; F, female; Mng, meningioma.
1Focal and diffuse refer to the pattern of NHERF1 microlumen staining on a representative section.
2Grade I meningiomas listed here include the following variants: meningothelial (n = 5), transitional (n = 3), fibrous (n = 2), psammomatous (n = 2), microcystic (n = 1).
3One of the 12 secretory meningioma cases was diagnosed as WHO grade II based on increased mitotic activity.
4Part chordoid meningioma cases contained less than 50% chordoid histology in the entire tumor.