Skip to main content
. 2018 Jun 19;9(47):28547–28560. doi: 10.18632/oncotarget.25558

Figure 4. PTC596 and ibrutinib cooperatively induce mitochondrial apoptosis in mantle cell lymphoma cells.

Figure 4

(A) REC-1 cells were treated with PTC596 (75, 150, or 300 nM for 24 hours) and ibrutinib (IBR) (0.05, 0.1, or 0.2 μM for 96 hours) either as individual agents or in combination, after which the annexin V-positive fractions were determined. (B) REC-1 cells were treated for with PTC596 (150 nM, 24 hours) and ibrutinib (IBR) (0.1 μM, 96 hours) either as individual agents or in combination, after which BAX conformational changes, caspase-3 cleavage and Δψm loss were determined.