Table 1. Anti-proliferative and apoptotic effects of PTC-209 and PTC596 in mantle cell lymphoma (MCL) cell lines.
| IC50 | ED50 | |||
|---|---|---|---|---|
| PTC-209 (μM) |
PTC596 (nM) |
PTC-209 (μM) |
PTC596 (nM) |
|
| REC-1 | 2.7 | 136 | 6.7 | 314 |
| NCEB-1 | 11.2 | 340 | >50 | 438 |
| MINO | 2.5 | 122 | 9.9 | 331 |
| MAVER-1 | 2.8 | 144 | 5.0 | 271 |
| JVM-2 | 3.0 | 208 | 21.6 | 507 |
| Granta-519 | 9.2 | 251 | 22.5 | 498 |
| JeKo-1 | 0.9 | 68 | 2.7 | 291 |
| Z-138 | 1.5 | 95 | 7.6 | 150 |
IC50, inhibitory concentration at which cell proliferation is inhibited by 50% as determined by trypan blue dye exclusion assay; ED50, effective concentration inducing 50% killing as measured by annexin V positivity.