Table 3. Combination index (CI) values for anti-proliferative and apoptotic effects.
| Cell line | CI for anti-proliferative effect | CI for apoptotic effect | |||||||
|---|---|---|---|---|---|---|---|---|---|
| IC50 | IC75 | IC90 | Averaged CI from IC50, IC75 and IC90 | ED50 | ED75 | ED90 | Averaged CI from ED50, ED75 and ED90 | ||
| PTC596 | Z-138 | 1.3 | 1.1 | 1.0 | 1.1 | 1.1 | 1.0 | 1.0 | 1.1 |
| + doxorubicin | JVM-2 | 0.7 | 0.9 | 1.4 | 1.0 | 1.1 | 1.0 | 1.0 | 1.0 |
| MAVER-1 | 1.1 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | |
| PTC596 | Z-138 | 1.2 | 1.1 | 1.1 | 1.1 | 1.2 | 1.2 | 1.1 | 1.2 |
| + bortezomib | JVM-2 | 0.8 | 0.9 | 1.2 | 1.0 | 1.1 | 1.2 | 1.2 | 1.2 |
| MAVER-1 | 1.3 | 1.2 | 1.1 | 1.2 | 1.1 | 1.2 | 1.3 | 1.2 | |
| PTC596 | Z-138 | 1.7 | 1.4 | 1.3 | 1.5 | 1.5 | 1.5 | 1.6 | 1.5 |
| + cytarabine | JVM-2 | 1.0 | 1.2 | 1.8 | 1.3 | 1.9 | 2.4 | 3.0 | 2.4 |
| MAVER-1 | 2.2 | 1.3 | 0.9 | 1.5 | 1.6 | 1.9 | 2.6 | 2.3 | |