Fig 10. Quercetin abrogates progression of emphysematous changes in RV-infected mice with COPD phenotype.

(A) Lung sections from sham- or infected mice with COPD phenotype maintained on control or quercetin diet and normal mice were stained with H & E and the diameters of the air spaces were measured in at least 10 random fields per section. (B to D) anesthetized mice intubated and connected to mechanical ventilator were used to measure dynamic compliance and elastance, and pressure-volume relationship. Data (A to C) represent median with range calculated from two independent experiments with 6 mice per group in total (* p≤0.05, different from respective sham; § p≤0.05, different from normal sham; ‡ p≤0.05, different from normal RV; @ p≤0.05, different from RV-infected COPD mice on control diet, ANOVA on ranks with Kruskal-Wallis H test). Data in (D and E) are representative of 6 mice per group.