. 2018 Jul 5;13(7):e0199840. doi: 10.1371/journal.pone.0199840

Table 9. Effects of increasing levels of lovastatin on blood biochemistry and hematology.

	Dietary treatments				SEM	Significance
	Control	Low	Medium	High	SEM	Significance
Enzymes (U/L)
Alkaline phosphatase	184.20	356.20	141.80	250.00	59.459	0.639
Aspartate aminotransferase	72.20	67.40	71.60	140.00	15.736	0.314
Alanine aminotransferase	27.60	23.00	25.60	21.40	1.903	0.702
Lactate dehydrogenase	218.60	194.00	202.80	252.40	16.576	0.648
Creatine kinase	160.80	239.20	135.00	272.20	26.627	0.226
Cholesterol (mmol/L)
Triglyceride	0.37	0.31	0.34	0.33	0.021	0.784
Cholesterol	1.86^a	0.94^b	0.72^b	0.64^b	0.120	<0 .001
Low density lipoprotein	0.62^a	0.31^b	0.31^b	0.37^b	0.036	0.001
High density lipoprotein	1.43^a	0.88^b	0.67^c	0.71^bc	0.075	<0 .001
White blood cells (x10⁹/L)
Total white blood cells	12.48	10.91	9.44	9.28	0.665	0.300
Neutrophils	6.52	6.15	5.38	4.52	0.356	0.195
Lymphocytes	3.12	3.20	2.89	3.59	0.276	0.864
Monocytes	0.63	0.64	0.49	0.51	0.040	0.459
Eosinophils	1.71^a	0.59^b	0.35^b	0.45^b	0.185	0.017
Basophils	0.30^a	0.14^b	0.16^b	0.12^b	0.026	0.040

Control, Low, Medium and High represent 0, 2, 4 and 6 mg lovastatin/kg BW/day, respectively

Different superscript lowercase letters in each row indicate significant differences