Table 2. Intracerebral inoculation of tgBov mice with a panel of tissues collected from a Sh-BSE clinically affected pig.
Inocula | Brain | Sciatic nerve | Brachial nerve | Mesenteric lymph node | Oculomotor muscle | Ileum | Spleen | WBC |
---|---|---|---|---|---|---|---|---|
Positive micea | 5/5 | 5/6 | 2/6 | 1/5 | 5/5 | 0/5 | 0/5 | 0/5 |
Incubationb | 306±85 | 402± 76 | 478±0 | 477 | 412 ±86 | - | - | - |
a Data based on PrPres detection in the brain
b Incubation periods were calculated as the number of days between inoculation and the onset of clinical signs consistent with a prion disease, at which time mice were euthanized. Incubation periods are shown as mean±SEM days post-inoculation