Table 3. Univariate and multivariate Cox regression analysis for disease-free survival in patients with stage II and III colorectal cancer according to FUT8 expression and the p53 status.
| n | Univariate | Multivariate † | |||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95%CI | P | HR | 95%CI | P | ||||
| Immunohistochemistry cohort (n = 123) | |||||||||
| p53 negative | |||||||||
| FUT8 protein Low | 17 | 1 (Reference) | 1 (Reference) | ||||||
| FUT8 protein High | 49 | 0.28 | 0.10–0.76 | 0.012 | 0.31 | 0.11–0.88 | 0.027 | ||
| p53 positive | |||||||||
| FUT8 protein Low | 13 | 1 (Reference) | 1 (Reference) | ||||||
| FUT8 protein High | 44 | 1.25 | 0.27–5.88 | 0.778 | 1.47 | 0.30–7.22 | 0.634 | ||
| Microarray cohort (n = 357) ‡ | |||||||||
| p53 wild-type | |||||||||
| FUT8 mRNA Low | 79 | 1 (Reference) | 1 (Reference) | ||||||
| FUT8 mRNA High | 76 | 0.72 | 0.41–1.28 | 0.261 | 0.74 | 0.42–1.31 | 0.303 | ||
| p53 mutant | |||||||||
| FUT8 mRNA Low | 102 | 1 (Reference) | 1 (Reference) | ||||||
| FUT8 mRNA High | 100 | 1.02 | 0.64–1.64 | 0.926 | 1.00 | 0.63–1.61 | 0.991 | ||
HR, hazard ratio; CI, confidence interval.
† The multivariate models were adjusted for variables that were significant in the univariate analysis.
‡ In the microarray cohort, univariate and multivariate models were also adjusted for cohort membership.