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. 2018 Jun 22;14(6):e1006165. doi: 10.1371/journal.pcbi.1006165

Fig 1. Hybrid structural method for predicting the 3D structure of apoE4 bound to rHDL.

Fig 1

The molecular structure of lipidated apolipoprotein E4 (apoE4) is elucidated by using a combination of experimental techniques, e.g. chemical cross-linking coupled to mass spectrometry (XL-MS), transmission electron microscopy (TEM) and native gel electrophoresis (native PAGE) combined with molecular modeling (MM) and molecular dynamics (MD). Each step of this study is depicted in the black framed boxes. The red framed box indicates data coming from the literature. Blue arrows indicate data used as input for the different steps of the modeling process and black arrows the workflow of the structural modeling.