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. 2018 Jun 22;14(6):e1006165. doi: 10.1371/journal.pcbi.1006165

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© 2018 Henry et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — (A) ApoE4 nanodiscs cross-linked by DSS and analyzed by SDS-PAGE (8%) stained with Coomassie blue. Cross-linking was carried out with a 8:1 molar ratio of DSS:apoE4 at 0.5 mg/ml apoE4 concentration. (B) Overview of the intramolecular XLs obtained for apoE4 nanodiscs after XL-MS analysis of the apoE4 monomeric band. Helices 1, 2, 3 and 4 from the NT domain are colored in blue, red, yellow and green respectively. The CT domain helices are colored in purple. Intra-NT domain XLs are shown by dashed lines, intra-CT domain XL by a straight line and NT to CT domain XLs by dotted lines. (C) Model of a hairpin conformation suggested by the extensive number and variety of NT to CT domain XLs. (D) Compact state of the NT domain suggested by the different intra-NT domain XLs.