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. Author manuscript; available in PMC: 2018 Jul 5.
Published in final edited form as: Biochemistry. 2018 Apr 12;57(16):2325–2334. doi: 10.1021/acs.biochem.8b00357

Figure 2.

Figure 2

Position of the N-terminus of the human E2p IC domain. (A) Space-filling models of the IC trimers of human E2p and A. vinelandii E2p, showing how the N-terminal arm of each domain of a trimer extends along an outer edge of a trimer as seen in the 3-fold exterior view. (B) Residues 408–416 of human E2p, corresponding to the region of A. vinelandii E2p structure extending to the 3-fold axis, are not visible in the EM map (transparent gray surface). In contrast to the structure of A. vinelandii E2p, the resolvable N-terminal residues of human E2p, E. coli E2o, and bovine E2b are in similar positions close to the 2-fold axis.