Fig 5. Label incorporation, telomere length, and YFV predictions for CD8⁺ T_N and T_SCM cells.

(A) Fit of the explicit heterogeneity model to isotope labelling data from CD8⁺ T_N and T_SCM cells and to the YFV-specific T_SCM data. Experimental data are represented by solid black symbols. (B) fits to the average telomere length differences (Θ) between the CD8⁺ T_N and T_SCM pools, experimental data shown in red. The number of bps lost per division was taken to be δ = 50 bp/division. Isotope labelling, telomere length, and the YFV data were fitted simultaneously. (C) Schematic summary of estimated T_N and T_SCM dynamics. Estimates are the medians across subjects obtained from the fits shown in panels A and B. Parameter estimates for each subject are provided in Table 1 and S2 Table. The size of the squares is proportional to the population size. Labelling data and telomere data are provided in S1 Data; the YFV tetramer data were previously published [21]. bp, base pair; T_N, naïve T; T_SCM, stem cell–like memory T; YFV, yellow fever virus.