Fig 6. Stochastic dynamics of the long-lived antigen-specific T_SCM populations.

Gillespie simulations of the change in size of antigen-specific precursor populations within the long-lived T_SCM pool were performed for each individual. (A) Distribution of antigen-specific precursor population half-lives. (B) Five randomly chosen Gillespie simulations for the 2 subjects exhibiting the most interrealisation variation (DW01 and DW10). Simulations were performed using the T_SCM parameters estimated by fitting the explicit heterogeneity model (Table 1 and S2 Table). All results depicted are provided in S1 Data. T_SCM, stem cell–like memory T.