Key resources table.

Reagent type (species) or resource	Designation	Source or reference	Identifiers	Additional information
Cell line (H. sapiens)	SF7761	PMID: 23603901	RRID:CVCL_IT45	Growth in neural stem cell media as neurosphere
Cell line (H. sapiens)	SF8628	PMID: 25401693	RRID:CVCL_IT46	Growth in DMEM as monolayer
Cell line (H. sapiens)	KNS42	PMID: 25401693	RRID:CVCL_0378	Growth in DMEM as monolayer
Cell line (H. sapiens)	SF9427	PMID: 25401693		Growth in DMEM as monolayer
Cell line (H. sapiens)	PED8	PMID: 26376656		Growth in neural stem cell media as neurosphere
Antibody	H3K27me3	Cell Signaling	C36B11, RRID:AB_2616019	1.4 µg for ChIP, 1:1000 for Western blot
Antibody	Ezh2	Cell Signaling	5246, RRID:AB_10694683	5 µg for ChIP, 1:1000 for Western blot
Antibody	Suz12	Cell Signaling	3737S, RRID:AB_2196850	1:1000 for Western blot
Antibody	H3K27ac	Abcam	ab4729, RRID:AB_2118291	2 µg for ChIP, 1:1000 for Western blot
Antibody	H3K4me1	Abcam	ab8895, RRID:AB_306847	2 µg for ChIP, 1:1000 for Western blot
Antibody	α-Tubulin	Sigma	T9026, RRID:AB_477593	1:1000 for Western blot
Antibody	FLAG	Sigma	F1804, RRID:AB_262044	2 µg for ChIP, 1:1000 for Western blot
Antibody	H3K27M	Millipore	ABE419, RRID:AB_2728728	2 µg for ChIP, 1:1000 for Western blot
Antibody	HA	This study	12CA5	2 µg for ChIP, 1:1000 for Western blot
Antibody	H3	PMID: 23603901		1:10000 for Western blot
Commercial assay or kit	SuperScript III First-Strand kit	Invitrogen	18080–051
Commercial assay or kit	RNeasy Mini Kit	Qiagen	74104
Commercial assay or kit	QiaQuick PCR purification kit	Qiagen	28104
Commercial assay or kit	ssoAdvanced Universal SYBR Green Supermix	Bio-Rad	1725274
Commercial assay or kit	cell titer blue assay kit	Promega	G8081
Software, algorithm	Bowtie2	PMID: 22388286	RRID:SCR_005476
Software, algorithm	MACS2	PMID: 18798982	RRID:SCR_013291
Software, algorithm	Bedtools	PMID: 20110278	RRID:SCR_006646