Table 1.
Summary of g-factors determined for chiral drug substances.
| Drug Substance | Solventa,b | Elution Method | Wavelength (nm) | g-Factors (x1e4)
|
|
|---|---|---|---|---|---|
| Spectrum | HPLC-CD | ||||
| Dexchlorpheniramine | ACN-potassium phosphate (40 mM) (pH* 3.0) | Gradient | 245 | 5.89 | 6.50 |
| Dextromethorphan | ACN-ammonium nitrate (23 mM), docusate sodium (23 mM) (7:3) (pH*3.4) | Isocratic | 280 | 6.27 | 7.18 |
| (S)-citalopram | ACN-potassium phosphate (25 mM) (pH* 3.0) | Gradient | 242 | 4.87 | 5.44 |
| Esomeprazole | ACN-sodium phosphate (9 mM) (pH* 7.6) (7:3) | Isocratic | 230 | 12.30 | 12.78 |
| Levalbuterol | ACN-methanol-phosphoric acid-water | Gradient | – | – | – |
| Levetiracetam | ACN-potassium phosphate (20 mM) (pH* 5.5) | Gradient | 230 | −124.82 | −167.05 |
| Levocetirizine | ACN-water-sulfuric acid (4 mM) (930:66:4) | Isocratic | 230 | 3.64 | 3.92 |
| Levofloxacin | Methanol-ammonium acetate (11 mM), cupric sulfate (5 mM), L-isoleucine (10 mM) (3:7) | Isocratic | 230 | −5.31 | – |
| Pramipexole | ACN-potassium phosphate (67 mM), sodium 1-octanesulfonate (23 mM) (pH* 3.0) | Gradient | 240 | −3.11 | −2.90 |
| Sitagliptin | ACN-potassium phosphate (10 mM) (pH* 2.0) (3:17) | Isocratic | – | – | – |
| Timolol | ACN-water (0.05% trifluoroacidic acid) | Gradient | – | – | – |
| Tolterodine | ACN-water (0.01% phosphoric acid) (33:67) | Isocratic | 231 | 16.65 | 14.87 |
| Valsartan | ACN-water (0.01% acetic acid) (1:1) | Isocratic | 233 | −3.79 | −4.43 |
a
ACN refers to acetonitrile.
b
All isocratic conditions are reported as (v:v). Gradient details are provided in supplemental information.