Table 2.
Association between polygenic risk score of shorter telomere length and lifetime risk of depression and anxiety a,b
| Depression c | Anxiety d | |||
|---|---|---|---|---|
|
| ||||
| N (yes/no) | OR (95% CI) | N (yes/no) | OR (95% CI) | |
| Quintile 1 | 1407/1965 | 1.00 (ref) | 960/2150 | 1.00 (ref) |
| Quintile 2 | 1427/1941 | 1.04 (0.94–1.14) | 925/2208 | 0.94 (0.84–1.05) |
| Quintile 3 | 1429/1882 | 1.06 (0.94–1.19) | 971/2115 | 1.03 (0.92–1.15) |
| Quintile 4 | 1396/1971 | 1.00 (0.91–1.10) | 999/2110 | 1.07 (0.96–1.19) |
| Quintile 5 | 1398/2005 | 0.98 (0.89–1.08) | 953/2171 | 1.00 (0.89–1.11) |
| Per 1 SD increase | 7057/9764 | 0.99 (0.96–1.02) | 4808/10754 | 1.01 (0.98–1.05) |
All models adjust for age at baseline, first three genetic principal components-derived eigenvectors, and disease endpoints in original nested case-control studies.
Analyses were first conducted within each of the platform-specific genetic datasets and then a combined estimate was obtained using a random-effect meta-analysis. There was no effect heterogeneity between platforms. The estimates and p-values shown in the table were meta-analyzed results.
Depression was defined as self-reported doctor-diagnosed depression, regular antidepressant use, or the presence of severe depressive symptoms above clinical cutoff (Mental Health Index-5 ≤52 measured on the 1992Mental Health Index-5 ≤52 measured on the 1996, and 2000 questionnaires, 10-item Center for Epidemiologic Studies Depression ≥ 10 measured on the 2004 questionnaire, and/or 15-item Geriatric Depression Scale ≥ 6 measured on the 2012 questionnaire) anytime between 1992 and 2012 in the NHS cohort follow-up.
The presence of severe anxiety symptom was defined by Crown-Crisp Index ≥ 6 measured in 1988 and 2004 and/or Generalized Anxiety Disorder Questionnaire (GAD-7) ≥ 5 measured in 2012