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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: J Psychiatr Res. 2018 May 26;103:182–188. doi: 10.1016/j.jpsychires.2018.05.021

Table 3.

Association between polygenic risk score of shorter telomere length and long-term pattern of mid- to late-life depressive symptoms a,b

Trajectory of 20-year depressive symptoms N OR (95% CI)
Clinical range depressive symptoms, persistent 231 1.03 (0.91–1.18)
Clinical range depressive symptoms, improving 1097 1.00 (0.94–1.07)
Sub-threshold depressive symptoms, not improving 663 1.03 (0.95–1.12)
Mild depressive symptoms, not improving 2522 0.98 (0.92–1.05)
Minimal depressive symptoms 8699 1.00 (reference)
Sub-threshold depressive symptoms, improving 3188 1.01 (0.96–1.07)
a

Genetically-predicted telomere length was assessed by per 1 standard deviation increase in polygenic risk score of telomere length corresponding to risk alleles associated with shorter telomere length. All models adjust for age at baseline, first three genetic principal components-derived eigenvectors, and disease status of original nested case-control studies.

b

Analyses were first conducted within each of the platform-specific genetic datasets and then a combined estimate was obtained using a random-effect meta-analysis. There was no effect heterogeneity between platforms. The estimates and p-values shown in the table were meta-analyzed results.