Table 3.
Trajectory of 20-year depressive symptoms | N | OR (95% CI) |
---|---|---|
Clinical range depressive symptoms, persistent | 231 | 1.03 (0.91–1.18) |
Clinical range depressive symptoms, improving | 1097 | 1.00 (0.94–1.07) |
Sub-threshold depressive symptoms, not improving | 663 | 1.03 (0.95–1.12) |
Mild depressive symptoms, not improving | 2522 | 0.98 (0.92–1.05) |
Minimal depressive symptoms | 8699 | 1.00 (reference) |
Sub-threshold depressive symptoms, improving | 3188 | 1.01 (0.96–1.07) |
Genetically-predicted telomere length was assessed by per 1 standard deviation increase in polygenic risk score of telomere length corresponding to risk alleles associated with shorter telomere length. All models adjust for age at baseline, first three genetic principal components-derived eigenvectors, and disease status of original nested case-control studies.
Analyses were first conducted within each of the platform-specific genetic datasets and then a combined estimate was obtained using a random-effect meta-analysis. There was no effect heterogeneity between platforms. The estimates and p-values shown in the table were meta-analyzed results.