Table 4.
Association between polygenic risk score of shorter telomere length and the risk of later-life onset of depression and anxiety a,b
| Depression c | Anxiety d | |||
|---|---|---|---|---|
|
| ||||
| N (yes/no) | OR (95% CI) | N (yes/no) | OR (95% CI) | |
| Quintile 1 | 432/1342 | 1.00 (ref) | 356/1583 | 1.00 (ref) |
| Quintile 2 | 440/1356 | 1.03 (0.88–1.20) | 357/1682 | 0.91 (0.71–1.16) |
| Quintile 3 | 466/1308 | 1.10 (0.94–1.28) | 336/1603 | 0.93 (0.79–1.10) |
| Quintile 4 | 455/1375 | 1.06 (0.91–1.23) | 344/1565 | 0.98 (0.83–1.15) |
| Quintile 5 | 461/1353 | 1.07 (0.91–1.24) | 351/1628 | 0.95 (0.82–1.11) |
| Per 1 SD increase | 2254/6734 | 1.02 (0.97–1.07) | 1744/8061 | 1.00 (0.95–1.06) |
All models adjust for age at baseline, first three genetic principal components-derived eigenvectors, and disease status of original nested case-control studies.
Analyses were first conducted within each of the platform-specific genetic datasets and then a combined estimate was obtained using a random-effect meta-analysis. There was no effect heterogeneity between platforms. The estimates and p-values shown in the table were meta-analyzed results.
Only participants with age 60 years or above and with no prior history of depression in 2000 were included. New cases of depression was defined as self-reported doctor diagnosed depression, regular use of antidepressants, or depressive symptoms above the clinical cutoff (10-item Center for Epidemiologic Studies Depression ≥ 10 measured on the 2004 questionnaire and/or 15-item Geriatric Depression Scale ≥ 6 measured on the 2012 questionnaire) anytime after 2000 to 2012 in the NHS follow-up.
Only participants with age of 50 or above and with Crown-Crisp Index score of 3 points or below in 1988 were included. New cases of severe anxiety symptoms was defined by Crown-Crisp Index ≥ 6 measured in 2004 and/or Generalized Anxiety Disorder Questionnaire (GAD-7) ≥ 5 measured in 2012