Table 2.

Muscle radiodensity and mortality

			Overall Mortality				CRC Mortality
	SMD Range	At-risk	Events	HR	Lower bound, 95% CI	Upper bound, 95% CI	Events	HR	Lower bound, 95% CI	Upper bound, 95% CI
Low SMD by sex-specific optimal stratification			879				451
Normal	32.5 – 72.1	2296	481				259
Low	5.7 – 35.5	966	398	1.61	1.36	1.90	192	1.74	1.38	2.21
Quartiles of SMD
High	44.4 – 72.1	815	153				93
Mid-High	37.7 – 47.2	816	177	0.94	0.75	1.18	89	0.94	0.68	1.28
Mid-Low	30.8 – 41.0	816	201	0.95	0.75	1.21	109	1.10	0.79	1.53
Low	5.7 – 34.6	815	348	1.50	1.15	1.94	160	1.63	1.13	2.36
p for trend across quartiles						0.001				0.003
p for trend (continuous)						<0.0001				0.0001

"SMD"=skeletal muscle radiodensity (HU); HR=hazard ratio

Models simultaneously adjusted for muscle mass, visceral and subcutaneous adiposity in quartiles

Additionally adjusted for age at diagnosis (continuous), sex (ref=Male), race (ref=White), site (ref=Proximal), stage (ref=I), grade (ref=Well differentiated), chemotherapy (ref=No), radiation (ref=No), smoking history (ref=Never), comorbidity score (ref=0) and partitioned BMI (continuous)