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. Author manuscript; available in PMC: 2019 Jul 5.
Published in final edited form as: Nanoscale. 2018 Jul 5;10(25):11841–11849. doi: 10.1039/c8nr01646a

Figure 4. Performance evaluation of the developed nanoparticle-enhanced electrical sensing protocol of ZIKV on paper microchip.

Figure 4

(a) Schematic shows the effect of the addition of viral lysate and PtNPs on the electric properties of paper microchip. (b) The detection sensitivity of ZIKV on the developed paper microchip. Different concentrations of ZIKV (101 particle/μl to 105 particle/μl) were prepared in 1× PBS and captured using magnetic beads. (c) Evaluation of the specificity of the paper chip in detecting ZIKV in the presence of non-target viruses, including dengue virus-1 and -2 (DENV-1 and -2), cytomegalovirus (CMV), and human simplex virus-1 (HSV-1). The results showed a significant decrease in the impedance magnitude of ZIKV samples compared with the tested non-target viruses. The tested virus concentration was 105 particle/μl. Error bars are standard deviations from a total of three independent measurements.