Table 2.

Cost estimates for decision tree analysis of neoadjuvant chemotherapy versus primary debulking surgery for bulky advanced epithelial ovarian cancer

Event	PDS	NACT	Source
Debulking surgery	$2,095	$2,095	2015 Medicare Physician Fee Schedule[30]
Additional surgical procedures*	$924	$3,907	2015 Medicare Physician Fee Schedule[30]
Surgical hospitalization
Without complications	$11,470	$11,470	HCUPnet[29]
With major complications	$27,030	$27,030	HCUPnet[29]
Readmission for late complication*	$5,152	$5,152**	HCUPnet[29]
Death	$0	$0
Chemotherapy (3 rounds)	$1,254	$1,254	2015 ASP[31] + 6%, 2015 Medicare Physician Fee Schedule[30]

Abbreviations: PDS, primary debulking surgery; NACT, neoadjuvant chemotherapy; HCUP, Hospital Cost and Utilization Project; ASP, average sales price

^*Cost was calculated as the weighted average of results reported in Fagotti et al[26]; see Table S1 for individual procedures and probabilities.

^**No late complications were observed among NACT patients in Fagotti et al[26]; the cost of late complications were assumed to be equal to those of PDS when varying this probability in sensitivity analysis.