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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Neuropharmacology. 2018 Jan 5;142:270–276. doi: 10.1016/j.neuropharm.2018.01.005

FIGURE 1.

FIGURE 1

Psychoactive and Therapeutic Effects of a Single Sub-anesthetic Ketamine Infusion. Ketamine 0.71 mg/kg over 52 min (Ket) produced greater psychoactive effects on all measures than did midazolam 0.025 mg/kg over 52 min (Mdz) (a–c) as ascertained shortly after the infusion, and was also associated with greater post-infusion global improvement (d), which reflected improvement in subsequent cocaine self-administration, craving, and cocaine use in the natural ecology.