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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Addict Biol. 2018 Jan 5;24(2):251–264. doi: 10.1111/adb.12594

Figure 4.

Figure 4

Chemogenetic inhibition of direct pathway striatal neurons (dMSNs) has no effect on cue-induced reinstatement to sucrose-seeking across phenotype A, Illustration of the experimental paradigm. B,C, Low- (white) and high- (grey) responder phenotypes showed a significant difference in the total number of pellets earned (B, ***p=0.0002 and C, **main effect of phenotype, p=0.001). D, Active (grey circles) and inactive (white circles) responses during 4 sessions of extinction training; extinction responding did not differ between groups. E, The number of active responses were significantly increased in both phenotypes during cue-induced reinstatement (*p<0.05 vs. extinction (EXT)). Decreasing dMSN activity had no effect on the number of active responses in either phenotype during cue-induced reinstatement (#p<0.05 vs. vehicle (VEH)). The number of inactive responses (lower error bars) did not differ across groups. Light grey represents EXT, white represents VEH, dark grey represents CNO. Black circles and squares represent data points of individual animals. N=16.