Table 2.
Plasma biochemistry, kidney weight, and kidney lipid changes after coagonist treatment in diet-induced obese mice (46-48 wk old)
| Parameter/treatment | Vehicle control | Coagonist (150 µg/kg, sc) | Chow-fed control |
| Plasma creatinine (μmol/L) | 36.2 ± 4.1 | 17.6 ± 5.4a | 15.9 ± 2.3a |
| Plasma BUN (mg/dL) | 48.1 ± 5.8 | 24.8 ± 2.3a | 18.2 ± 4.2a |
| Urinary albumin (μg/d) | 210.7 ± 15.4 | 71.3 ± 5.8a | 50.9 ± 4.7a |
| Renal triglycerides (μg/mg of protein) | 64.8 ± 5.8 | 27.8 ± 8.4a | 25.3 ± 2.8a |
| Renal cholesterol (μg/mg of protein) | 22.5 ± 5.4 | 12.6 ± 3.3a | 5.7 ± 2.1a |
| Kidney weight (mg) | 541.2 ± 46.8 | 387.4 ± 14.8a | 210.3 ± 42.4a |
Data are shown as the mean ± SE.
a
P < 0.05, vs vehicle control. BUN: Blood urea nitrogen.