Table 2.
Clinical outcomes of liver resection in BCLC stage B or C hepatocellular carcinoma
| Ref. | Recruitment period | n |
Overall survival (%) |
Median OS (mo) |
Disease free survival (%) |
Median DFS (mo) | ||||
| 1-yr | 3-yr | 5-yr | 1-yr | 3-yr | 5-yr | |||||
| BCLC stage B | ||||||||||
| Régimbeau et al[25] | 1984-1996 | 94 | 69.0 | 45.0 | 31.0 | NS | 51.0 | 35.0 | 21.0 | NS |
| Hanazaki et al[19] | 1983-1997 | 133 | 70.0 | 38.0 | 28.0 | NS | 65.0 | 26.0 | 20.0 | NS |
| Ng et al[10] | 1982-2001 | 380 | 74.0 | 50.0 | 39.0 | 36.9 | 54.0 | 38.0 | 26.0 | 15.6 |
| Chen et al[26] (TP1) | 1990-2003 | 959 | 67.8 | 50.7 | 27.9 | 16.0 | 56.5 | 34.7 | 18.9 | 10.0 |
| Chen et al[26] (TP2) | 1990-2003 | 1143 | 71.2 | 58.8 | 38.7 | 19.0 | 61.5 | 38.6 | 23.8 | 17.0 |
| Cho et al[26] | 1998-2001 | 230 | 85.0 | 59.3 | 52.9 | NS | 58.3 | 40.0 | 31.7 | NS |
| Vitale et al[31] | 2000-2007 | 124 | 85.0 | 56.0 | NS | NS | NS | NS | NS | NS |
| Yang et al[11] | 1992-2002 | 260 | 87.0 | 55.5 | 38.2 | 45.5 | 82.4 | 51.0 | 35.0 | 36.7 |
| Zhou et al[29] (SX) | 2001-2003 | 56 | 69.6 | 32.1 | 21.1 | NS | 39.2 | 21.4 | 8.9 | NS |
| Zhou et al[29] (TCSX) | 2001-2003 | 52 | 73.1 | 40.4 | 30.7 | NS | 48.9 | 25.5 | 12.8 | NS |
| Delis et al[27] | 2002-2008 | 66 | 69.0 | 37.0 | 32.0 | 36.0 | 60.0 | 33.0 | 29.0 | 29.0 |
| Lin et al[30] | 2001-2007 | 93 | 83.0 | 49.0 | 30.0 | 27.6 | NS | NS | NS | NS |
| Ramacciato et al[28] | 2000-2006 | 51 | NS | NS | 56.1 | 68.0 | NS | NS | 41.3 | NS |
| Xu et al[21] | 1991-2004 | 165 | 75.6 | 57.4 | 40.2 | NS | NS | NS | NS | NS |
| Wei et al[22] | 2003-2007 | 51 | 84.3 | 54.9 | NS | NS | 70.2 | 45.4 | NS | NS |
| Zhou et al[20] | 1995-2002 | 85 | 93.8 | 56.2 | 47.0 | 56.0 | 74.3 | 34.4 | 14.8 | 36.0 |
| Chang et al[32] | 1991-2006 | 318 | 81.2 | 59.4 | 46.5 | NS | 55.8 | 39.4 | 31.9 | 6.0 |
| Hsu et al[34] | 2002-2010 | 268 | 82.0 | 68.0 | 46.0 | NS | NS | NS | NS | NS |
| Ma et al[23] | 1998-2011 | 178 | 77.0 | 26.0 | 10.0 | 27.9 | 49.0 | 18.0 | NS | 16.8 |
| Torzilli et al[12] | 1990-2009 | 737 | 88.0 | 71.0 | 57.0 | NS | 63.0 | 38.0 | 27.0 | NS |
| Zhong et al[120] | 2000-2007 | 660 | 91.0 | 67.0 | 44.0 | NS | NS | NS | NS | NS |
| BCLC stage C | ||||||||||
| Ohkubo et al[79] | 1985-1997 | 47 | 53.9 | 33.2 | 23.9 | NS | 31.2 | 17.9 | NS | NS |
| Wu et al[57] (SX 1st bifurcation) | 1990-1998 | 15 | 80.0 | 44.0 | 26.4 | NS | 67.0 | 32.0 | 21.1 | NS |
| Wu et al[57] (SX 1st) | 1990-1998 | 97 | 68.0 | 34.0 | 28.5 | NS | 51.0 | 22.0 | 20.4 | NS |
| Minagawa et al[58] | 1989-1998 | 18 | 82.0 | 42.0 | 42.0 | 40.8 | NS | NS | NS | 7.8 |
| Poon et al[59] | 1989-2000 | 20 | 30.0 | 13.3 | 13.3 | 6.0 | 15.0 | 5.0 | 5.0 | 2.9 |
| Fan et al[60] (SX, CHT) | 1997-2002 | 84 | 29.3 | 15.6 | NS | 15.1 | NS | NS | NS | NS |
| Fan et al[60] (SX) | 1997-2002 | 24 | 22.7 | 0.0 | NS | 10.1 | NS | NS | NS | NS |
| Pawlik et al[10] | 1984-1999 | 102 | 45.0 | 17.0 | 10.0 | 11.0 | NS | NS | NS | NS |
| Chen et al[62] (SX 1st) | 1990-2003 | 286 | 58.7 | 22.7 | 18.1 | 18.8 | NS | NS | NS | NS |
| Chen et al[62] (SX Main) | 1990-2003 | 152 | 39.5 | 5.7 | 0.0 | 10.1 | NS | NS | NS | NS |
| Ikai et al[64] | 1990-2002 | 78 | 45.7 | 21.7 | 10.9 | 8.9 | NS | NS | NS | NS |
| Le Treut et al[63] | 1988-2004 | 26 | 38.5 | 20.0 | 13.0 | 9.0 | NS | NS | NS | NS |
| Kamiyama et al[66] (RTSX) | 1990-2006 | 15 | 86.2 | 43.5 | 34.8 | 19.6 | NS | NS | NS | NS |
| Kamiyama et al[66] (SX) | 1990-2006 | 28 | 39.0 | 13.1 | 13.1 | 9.1 | NS | NS | NS | NS |
| Takizawa et al[65] | 1992-2003 | 12 | 63.6 | 53.0 | 26.0 | 26.0 | NS | NS | NS | NS |
| Ban et al[69] | 1992-2008 | 45 | 69.6 | 37.4 | 22.4 | 20.0 | 30.4 | 21.2 | 0.0 | NS |
| Inoue et al[70] (TB) | 1995-2006 | 20 | 58.0 | 46.0 | 39.0 | NS | 34.0 | 34.0 | 23.0 | NS |
| Inoue et al[70] (EN) | 1995-2006 | 29 | 65.0 | 41.0 | 41.0 | NS | 38.0 | 22.0 | 18.0 | NS |
| Kondo et al[68] (SX, Main) | 1996-2004 | 5 | 20.0 | NS | NS | NS | NS | NS | NS | NS |
| Kondo et al[68] (SX, 1st-3rd) | 1996-2004 | 43 | 54.0 | 33.0 | 27.0 | NS | NS | NS | NS | NS |
| Peng et al[67] (TC) | 1996-2004 | 51 | 50.9 | 33.8 | 21.6 | 13.0 | NS | NS | NS | NS |
| Peng et al[67] (SX) | 1996-2004 | 53 | 33.3 | 17.0 | 8.5 | 9.0 | NS | NS | NS | NS |
| Vitale et al[31] | 2000-2007 | 48 | 55.0 | 44.0 | 0.0 | NS | NS | NS | NS | NS |
| Shi et al[71] | 2001-2003 | 406 | 34.4 | 13.0 | NS | NS | 13.3 | 4.7 | NS | NS |
| Xu et al[21] | 1991-2004 | 95 | 37.5 | 18.2 | 14.2 | NS | NS | NS | NS | NS |
| Lin et al[72] (TP1) | 1996-2006 | 21 | 77.0 | 19.0 | 5.0 | 21.0 | NS | NS | NS | NS |
| Lin et al[72] (TP2) | 1996-2006 | 47 | 76.0 | 51.0 | 36.0 | 36.0 | NS | NS | NS | NS |
| Peng et al[14] | 2002-2007 | 201 | 42.0 | 14.1 | 11.1 | 20.0 | NS | NS | NS | NS |
| Wei et al[22] | 2003-2007 | 17 | 52.9 | 29.4 | NS | NS | 35.2 | 17.6 | NS | NS |
| Chang et al[32] | 1990-2009 | 34 | 45.0 | 20.0 | 20.0 | NS | NS | NS | NS | NS |
| Huang et al[56] (SX) | 1991-2006 | 160 | 57.6 | 33.8 | 29.1 | NS | 35.3 | 27.2 | 25.0 | NS |
| Huang et al[56] (SXTC) | 1998-2008 | 54 | 71.0 | 35.0 | 11.0 | NS | NS | NS | NS | NS |
| Liu et al[74] | 1998-2008 | 62 | 71.0 | 24.0 | 6.0 | NS | NS | NS | NS | NS |
| Ma et al[23] | 2000-2009 | 65 | 84.0 | NS | NS | 17 | 79.0 | NS | NS | 14.0 |
| Li et al[75] | 1998-2011 | 46 | 37.0 | 16.0 | NS | 16.9 | 16.0 | NS | NS | 7.7 |
| Nitta et al[77] | 1997-2009 | 13 | 53.8 | 15.4 | NS | NS | NS | NS | NS | NS |
| Roayaie et al[78] | 2006-2008 | 35 | 78.0 | 37.4 | 32.7 | NS | 45.0 | 11.8 | 11.8 | NS |
| Tang et al[76] | 1992-2010 | 164 | 50.0 | 23.0 | 14 | 13.1 | 40.0 | 20.0 | 18.0 | 8.1 |
| Torzilli et al[12] | 2006-2008 | 186 | 40.1 | 13.6 | NS | 10.0 | NS | NS | NS | NS |
| Zhong et al[120] | 1990-2009 | 297 | 76.0 | 49.0 | 38.0 | NS | 46.0 | 28.0 | 18.0 | NS |
| Ohkubo et al[79] | 2000-2007 | 248 | 81.0 | 46.0 | 20.0 | NS | NS | NS | NS | NS |
TP: Time period; SX: Surgery; TC: Trans- arterial chemoembolization; CHT: Chemotherapy; TB: Thrombectomy; EN: En.bloc, RT: Radiotherapy.