Table 3.
Characteristics of patients classified as large or small hepatocellular carcinoma
| Ref. | Year | n | Male (%) | Cirrhosis (%) | HBV (%) | HCV (%) | Median tumor diameter (cm) |
| Large HCC | |||||||
| Poon et al[36] | 2002 | 120 | 99 (82.5) | 32 (26.7) | 103 (85.8) | NS | 13.8 |
| Yeh et al[38] | 2003 | 211 | 164 (77.7) | 63 (29.9) | 163 (77.3) | 16 (7.6) | 13.9 |
| Zhou et al[37] | 2003 | 621 | NS | NS | NS | NS | NS |
| Liau et al[41] | 2005 | 82 | 48 (58.5) | 8 (9.8) | NS | NS | 14.7 |
| Nagano et al[40] | 2005 | 26 | 19 (73.1) | 5 (19.2) | 14 (53.8) | 3 (11.5) | 14.8 |
| Pawlik et al[10] | 2005 | 300 | 222 (74.0) | NS | 188 (62.7) | NS | NS |
| Lee et al[43] | 2007 | 100 | 77 (77.0) | NS | NS | NS | 12.5 |
| Pandey et al[44] | 2007 | 166 | 143 (86.1) | 80 (48.2) | 130 (78.3) | 2 (1.2) | 13.0 |
| Shah et al[42] | 2007 | 24 | NS | NS | 9 (37.5) | 1 (4.2) | 13.1 |
| Young et al[45] | 2007 | 42 | 29 (69.0) | 2 (4.8) | NS | NS | 14.0 |
| Shimada et al[46] | 2008 | 85 | 72 (84.7) | NS | 27 (31.8) | 19 (22.4) | 12.0 |
| Taniai et al[47] | 2008 | 29 | 26 (89.7) | 12 (41.4) | 6 (20.7) | 17 (58.6) | 13.5 |
| Choi et al[50] | 2009 | 50 | 34 (68.0) | 13 (26.0) | 33 (66.0) | 1 (2.0) | NS |
| Miyoshi et al[49] | 2009 | 22 | 19 (86.4) | 5 (22.7) | NS | NS | 12.0 |
| Ng et al[48] | 2009 | 44 | 33 (75.0) | NS | 15 (34.1) | 3 (6.8) | 12.4 |
| Yamashita et al[51] | 2011 | 53 | 48 (90.6) | NS | 18 (34.0) | 22 (41.5) | 13.2 |
| Truant et al[35] | 2012 | 52 | 38 (73.1) | 23 (44.2) | 6 (11.5) | NS | 14.0 |
| Allemann et al[55] | 2013 | 22 | NS | 9 (40.9) | 4 (18.2) | 2 (9.1) | 13.5 |
| Ariizumi et al[54] | 2013 | 107 | NS | NS | NS | NS | NS |
| Shrager et al[52] | 2013 | 130 | 98 (75.4) | NS | 56 (43.1) | 23 (17.7) | 14.2 |
| Yang et al[53] | 2013 | 258 | 212 (82.2) | 171 (66.3) | 195 (75.6) | NS | 13.2 |
| Small HCC | |||||||
| Miyoshi et al[49] | 2009 | 230 | 160 (69.6) | 114 (49.6) | NS | NS | 3.4 |
| Allemann et al[55] | 2013 | 79 | NS | 61 (77.2) | 10 (12.7) | 13 (16.5) | 4.9 |
| Poon et al[36] | 2002 | 368 | 295 (80.2) | 203 (55.2) | 311 (84.5) | NS | 5.4 |
| Yeh et al[38] | 2003 | 778 | 776 (99.7) | 591 (76.0) | 616 (79.2) | 305 (39.2) | 4.5 |
| Zhou et al[37] | 2003 | 2039 | NS | NS | NS | NS | NS |
| Liau et al[41] | 2005 | 111 | 80 (72.1) | 40 (36.0) | NS | NS | 6.1 |
| Nagano et al[40] | 2005 | 143 | 112 (78.3) | 81 (56.6) | 17 (11.9) | 87 (60.8) | 3.3 |
| Shah et al[42] | 2007 | 165 | NS | NS | 73 (44.2) | 36 (21.8) | 4.7 |
| Young et al[45] | 2007 | 43 | 30 (69.8) | 10 (23.3) | NS | NS | 5.0 |
| Taniai et al[47] | 2008 | 291 | 225 (77.3) | 156 (53.6) | 135 (46.4) | 78 (26.8) | 3.7 |
| Choi et al[50] | 2009 | 447 | 344 (77.0) | 244 (54.6) | 331 (74.0) | 26 (5.8) | NS |
| Yamashita et al[51] | 2011 | 412 | 328 (79.6) | NS | 60 (14.6) | 311 (75.5) | 3.8 |
| Truant et al[35] | 2012 | 37 | 28 (75.7) | 26 (70.3) | 1 (2.7) | NS | 4.7 |
| Yang et al[53] | 2013 | 293 | 236 (80.5) | 201 (68.6) | 216 (73.7) | NS | 6.7 |
HCC: Hepatocellular carcinoma.