Table 4.
Clinical outcomes of liver resection in large or small hepatocellular carcinoma
| Ref. | Recruitment period | n |
Overall survival (%) |
Median OS (mo) |
Disease free survival (%) |
Median DFS (mo) | ||||
| 1-yr | 3-yr | 5-yr | 1-yr | 3-yr | 5-yr | |||||
| Large HCC | ||||||||||
| Poon et al[36] | 1991-2000 | 120 | 60.6 | 37.8 | 27.5 | 18.8 | 32.0 | 14.1 | 9.5 | 5.5 |
| Yeh et al[38] | 1982-2001 | 211 | 48.1 | 24.0 | 16.7 | NS | 32.9 | 18.8 | 12.7 | NS |
| Zhou et al[37] | 1964-1999 | 621 | 68.0 | 37.3 | 26.2 | NS | NS | NS | NS | NS |
| Liau et al[41] | 1985-2002 | 82 | 73.0 | 49.0 | 33.0 | 32.0 | 80.0 | 44.0 | 24.0 | 22.0 |
| Nagano et al[40] | 1985-2001 | 26 | 41.0 | 29.3 | 29.3 | 10.1 | 65.4 | 49.0 | NS | 29.0 |
| Pawlik et al[10] | 1981-2000 | 300 | 64.9 | 36.7 | 26.9 | 20.3 | NS | NS | NS | NS |
| Lee et al[43] | 1997-2003 | 100 | 66.0 | 44.0 | 31.0 | NS | 43.0 | 26.0 | 20.0 | NS |
| Pandey et al[44] | 1995-2006 | 166 | 65.0 | 35.0 | 28.6 | 20.0 | NS | NS | NS | NS |
| Shah et al[42] | 1993-2004 | 24 | 69.0 | 63.0 | 54.0 | NS | 41.0 | 23.0 | NS | 8.4 |
| Young et al[45] | 1994-2006 | 42 | 70.0 | 45.0 | 45.0 | NS | 62.0 | 49.0 | 43.0 | NS |
| Shimada et al[46] | 1988-2004 | 85 | NS | NS | 31.5 | NS | NS | NS | NS | NS |
| Taniai et al[47] | 1987-2006 | 29 | 51.9 | 33.6 | 33.6 | NS | 48.4 | 21.5 | 21.5 | NS |
| Choi et al[50] | 1996-2006 | 50 | 70.0 | 50.2 | 40.2 | NS | 49.0 | 38.6 | 38.6 | 9.0 |
| Miyoshi et al[49] | 1987-2004 | 22 | 71.8 | 60.3 | 45.2 | 20.5 | 53.3 | 29.1 | 18.2 | 12.0 |
| Ng et al[48] | 1990-2008 | 44 | 66.4 | 38.1 | 27.8 | 21.5 | 49.6 | 23.9 | 19.1 | 10.7 |
| Yamashita et al[51] | 1995-2007 | 53 | 74.0 | 43.0 | 35.0 | NS | 50.0 | 40.0 | 24.0 | NS |
| Truant et al[35] | 2000-2010 | 52 | NS | NS | 43.3 | NS | NS | NS | 39.3 | NS |
| Allemann et al[55] | 1997-2009 | 22 | 84.0 | 72.0 | 45.0 | 27.0 | 64.0 | 28.0 | 27.0 | 10.0 |
| Ariizumi et al[54] (S) | 1990-2008 | NS | 81.0 | 60.0 | 47.0 | 14.3 | 41.0 | 18.0 | 12.0 | NS |
| Ariizumi et al[54] (M) | 1990-2008 | NS | 88.0 | 83.0 | 79.0 | 38.5 | 76.0 | 54.0 | 48.0 | NS |
| Shrager et al[52] | 1992-2010 | 130 | 56.9 | 30.2 | 18.8 | 17.0 | 31.8 | 13.4 | 11.5 | 6.7 |
| Yang et al[53] | 2002-2011 | 258 | 84.0 | 62.0 | 33.0 | NS | 61.0 | 24.0 | 6.0 | NS |
| Small HCC | ||||||||||
| Miyoshi et al[49] | 1987-2004 | 230 | 89.3 | 74.6 | 60.4 | 48.2 | 68.0 | 43.7 | 26.7 | 20.0 |
| Allemann et al[55] | 1997-2009 | 79 | 75.0 | 42.0 | 21.0 | 24.0 | 50.0 | 18.0 | 14.0 | 15.0 |
| Poon et al[36] | 1991-2000 | 368 | 83.3 | 64.2 | 51.6 | 62.8 | 64.6 | 41.8 | 28.2 | 25.4 |
| Yeh et al[38] | 1982-2001 | 778 | 81.4 | 57.3 | 39.5 | NS | 61.2 | 40.7 | 32.1 | NS |
| Zhou et al[37] | 1964-1999 | 2039 | 85.0 | 65.1 | 54.3 | NS | NS | NS | NS | NS |
| Liau et al[41] | 1985-2002 | 111 | 80.0 | 58.0 | 39.0 | 40.0 | 70.0 | 49.0 | 31.0 | 28.0 |
| Nagano et al[40] | 1985-2001 | 143 | 93.1 | 74.5 | 44.7 | 53.4 | 80.0 | 46.5 | 31.0 | 33.9 |
| Shah et al[42] | 1993-2004 | 165 | 88.0 | 70.0 | 53.0 | NS | 76.0 | 53.0 | 43.0 | 38.0 |
| Young et al[45] | 1994-2006 | 43 | 82.0 | 63.0 | 57.0 | NS | 71.0 | 54.0 | 48.0 | NS |
| Taniai et al[47] | 1987-2006 | 291 | 81.0 | 61.4 | 45.0 | NS | 74.6 | 37.1 | 25.4 | NS |
| Choi et al[50] | 1996-2006 | 447 | 91.3 | 77.2 | 65.9 | NS | 72.7 | 53.1 | 45.4 | 35.0 |
| Yamashita et al[51] | 1995-2007 | 412 | 89.0 | 67.0 | 54.0 | NS | 72.0 | 45.0 | 37.0 | NS |
| Truant et al[35] | 2000-2010 | 37 | NS | NS | 89.2 | NS | NS | NS | 60.7 | NS |
| Yang et al[53] | 2002-2011 | 293 | 83.0 | 66.0 | 39.0 | NS | 56.0 | 26.0 | 9.0 | NS |
HCC: Hepatocellular carcinoma; M: Multi nodules; S: Single nodule.