Table 2.

Suggested therapy in response to measured hemodynamic parameters in children with septic shock

Hemodynamic parameters	Pathophysiological mechanism	Treatment
High SVRI, low CI and normal BP	Increased afterload Decreased contractility	Inodilators (milrinone, levosimendan)
Low SVRI, low CI and low BP	Decreased afterload Decreased contractility	Vasopressors (norepinephrine, epinephrine) Dobutamine if CI remains low
Low SVRI, high CI and low BP	Decreased afterload Good contractility	Vasopressors (norepinephrine or low dose vasopressin) Dobutamine or low dose epinephrine if CI decreased

SVRI: Systemic vascular resistance index; CI: Cardiac index; BP: Blood pressure.