Table 3.
Univariate and multivariate analysis of factors associated with overall survival
|
Univariate |
Multivariate |
|||
| HR (95%CI) | P value | HR (95%CI) | P value | |
| Gender | ||||
| Male | 1 | |||
| Female | 1.083 (0.62-1.88) | 0.775 | ||
| Age (yr) | 0.998 (0.97-1.02) | 0.905 | ||
| HBV | ||||
| No | 1 | |||
| Yes | 1.032 (0.59-1.79) | 0.909 | ||
| HCV | ||||
| No | 1 | |||
| Yes | 1.154 (0.56-2.37) | 0.696 | ||
| Platelet × 103 | 1.002 (0.99-1.00) | 0.117 | ||
| Tumor size (cm) | 1.062 (0.99-1.13) | 0.066 | ||
| No. of tumor | ||||
| Single | 1 | 1 | ||
| Multiple | 2.240 (1.27-3.94) | 0.005 | 1.991 (1.12-3.52) | 0.018 |
| mVI | ||||
| No | 1 | 1 | ||
| Yes | 3.324 (1.85-5.95) | 0 | 3.240 (1.77-5.90) | 0 |
| Stage | ||||
| Stage I | 1 | |||
| Stage II or higher | 1.941 (1.11-3.38) | 0.019 | ||
| Resection margin | ||||
| Free margin | 1 | |||
| Positive margin | 2.544 (1.00-6.47) | 0.05 | ||
| Anti-viral treatment | ||||
| No | 1 | |||
| Yes | 0.786 (0.45-1.36) | 0.392 | ||
| Recurrence | ||||
| No | 1 | |||
| Yes | 7.917 (3.56-17.56) | 0 | ||
| AFP | ||||
| Normal group | 1 | 1 | ||
| Response group | 1.338 (0.74-2.41) | 0.334 | 1.168 (0.64-2.12) | 0.612 |
| Non-response group | 3.635 (1.61-8.18) | 0.002 | 3.621 (1.59-8.21) | 0.002 |
AFP: Alpha-fetoprotein; HBV: Hepatitis B virus; HCV: Hepatitis C virus.