Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 5;8:10163. doi: 10.1038/s41598-018-28332-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Epigenetic analysis of DAO. (A) Structure of the DAO gene showing the putative regulatory upstream region (white box), exons (black box) and first intron (grey box). Transcriptional start site (+1) is indicated by an arrow. Vertical bars represent the relative position of each CpG site and the arrows indicate the primer positions. The gene sequence was retrieved by Ensemble database accession number: DAO ENSG00000110887. (B) The methylation average at each CpG site, between the two groups (CTRL: black circles; SCZ; open circles) for each region (HIPP, DLPFC and CB) is reported in the graphs. (C) The average methylation of controls (CTRL) and subjects with schizophrenia (SCZ) in hippocampus (HIPP), dorsolateral-prefrontal cortex (DLPFC) and cerebellum (CB) areas is reported in the histogram. (D) For each sample group and brain area, the number of mCpH and mCpG per molecule was calculated as described in the Materials and Methods section. The percent values of non-CpG methylation are reported in Table S2. (E) DAO mRNA expression levels in the HIPP, DLPFC and CB of control and schizophrenia patients were detected by quantitative RT-PCR and expressed as 2^−ΔCt. All data are shown as the mean ± standard error (SEM).