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. 2018 Jul 5;8:10219. doi: 10.1038/s41598-018-28545-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Minor morphological alterations of the cornea of Ubiad1^N100S mice. (A) Stereomicroscopy and H&E staining showed intact and clear cornea and normal cornea morphology for the Ubiad1^N100S mutant. Mice were six-month-old of mixed genders. (B) No Corneal epithelial barrier function and wound healing change. Representative images of corneal epithelial fluorescein staining of unwound, 0 h and 16 h after 2 mm debridement wounds of Ubiad1^WT/WT, Ubiad1^N100S/WT or Ubiad1^N100S/N100S mice. Grey levels of the images of unwound cornea revealed no significant difference in corneal epithelial barrier during different genotypes. The average defect remaining in Ubiad1^N100S/N100S, Ubiad1^N100S/WT and Ubiad1^WT/WT mice showed healing of epithelial debridement was similar between three groups. (C) In vivo confocal microscopy analysis of corneal deposits at 6 weeks. Representative extended focus images combined 5 confocal sections of basal epithelium to show the deposits within the cornea. Quantification of corneal deposit light scattering, and particle number was determined as described under the Methods. The two-tailed Student’s t-test was used to analyze the light scattering and particle numbers. Data are presented as mean ± SD. *p < 0.05, **p < 0.01. Mice were of mixed genders.